She started to paint using polka dots and nets as motifs at around age ten ,and created fantastic paintings in watercolors, pastels and oils.

Went to the United States in 1957. Showed large paintings, soft sculptures, and environmental sculptures using mirrors and electric lights. In the latter 1960s, staged many happenings such as body painting festivals, fashion shows and anti-war demonstrations. Launched media-related activities such as film production and newspaper publication. In 1968, the film “Kusama's Self-Obliteration"which Kusama produced and starred in won a prize at the Fourth International Experimental Film Competition in Belgium and the Second Maryland Film Festival and the second prize at the Ann Arbor Film Festival. Held exhibitions and staged happenings also in various countries in Europe.

Yayoi Kusama’s work has transcended two of the most important art movements of the second half of the twentieth century: Pop art and Minimalism. Her extraordinary and highly influential career spans paintings, performances, room-size presentations, outdoor sculptural installations, literary works, films, fashion, design, and interventions within existing architectural structures, which allude at once to microscopic and macroscopic universes.

I am deeply interested in trying to understand the relationship between people, society, and nature; and my work is forged from accumulations of these frictions.
— https://www.thebroad.org/art/special-exhibitions/yayoi-kusama-infinity-mirrors