Jacquemus was born into a relatively modest family of farmers; his father sang occasionally in metal bands and his mother raised him. He grew up in the small town of Mallemort in southern France and almost always hints at his coutryside childhood memories. In 2008, at the age of 18, he went to Paris, where he studied for a few months and worked as a sales clerk at Comme des Garçons store in Paris. He was 20 years old when he created his brand Jacquemus, which was his mother's maiden name. He promoted his designs by having friends wear his creations in shops during Vogue's Fashion Night Out in 2010 in Paris. In 2012, he was invited to present his collection during Paris Fashion Week.

His approach is a modernist French womenswear with an eye for deconstruction and an optimistic childlike spirit. Tho, that wasn’t his intention at first. He likes to begin with his desire to tell stories. He became obsessed with French culture, women and uniforms. His runway featured putting cut outs over the faces of the models. He sets out for a narrative driven approach with inspiration from french films from the 80s, with Jean Paul Belmondo or Gerard Depardieu. In his interview with SSENSE, he shared about his blog, “I had a blog when I was 13, 14, 15. It was very famous in France. It was like my Instagram now. I was telling a story per week: all stories were about me. Simon in the fields. Simon by the sea. Simon on the farm with my family.” He speaks about his naivety in starting the brand and how his minimialism approach was not due to his knowledge of designers like Jill Sander or Margiela, but rather because he had no money.

Vogue quoted in a recent article, “showgoers gathered around the Place Jacquemus “storefront” to snap photos of this new release for Fall, a bag so small it’s only big enough for AirPods, just impractical enough to be irresistible.”

Everyone thinks that because you’re from a farmer family you don’t get fashion or beauty. Farmers are the most poetic people, obsessed with beauty. My father had a band and would dress up in the evenings, for his performances, wearing these amazing big boots and singing rock. My mother was into decoration, she was obsessed with doing everything by hand, from the curtains to the furniture, everything in our house was made by her.
— https://www.ssense.com/en-us/editorial/fashion/home-alone-with-jacquemus